Thermo Fisher Scientific JAK1 Recombinant Rabbit Monoclonal Antibody (7Q1B2)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7Q1B2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 600-700 of human JAK1 (P23458). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:JAK1,uniProtId:P23458-1,ncbiNodeId:9606,antigenRange:600-700,antigenLength:1154,antigenImageFileName:MA5-42649_JAK1_P23458-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42649_JAK1_P23458-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911790

Product Specific Information

Positive test controls include: Mouse lung.

Immunogen sequence: GTLMDYKDDE GTSEEKKIKV ILKVLDPSHR DISLAFFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM HRKSDVLTTP WKFKVAKQLA S

Target Information

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.