Thermo Fisher Scientific NFATC2IP Polyclonal Antibody
NFATC2IP 단백질을 인식하는 Thermo Fisher의 토끼 폴리클로날 항체. 인간 시료 반응성, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 액상 포맷, 4°C 단기 보관 가능. 연구용 전용 제품.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human NFATC2IP. Recombinant protein control fragment (Product # RP-106479) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664113 |
Product Specific Information
Immunogen sequence:
SPWKTKLRTKD KEEKKKTEFL DLDNSPLSPP SPRTKSRTHT RALKKLSEVN KRLQDLRSCL SPKPPQGQEQ QGQEDEVVLV E
Highest antigen sequence identity to the following orthologs:
- Mouse: 67%
- Rat: 69%
Target Information
In T-helper 2 (Th2) cells, NFATC2IP regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5, and IL13, but not IL2. It recruits PRMT1 to the IL4 promoter, leading to enhancement of histone H4 Arg-3 methylation and facilitating subsequent histone acetylation at the IL4 locus, promoting robust cytokine expression. It also down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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