Thermo Fisher Scientific C16orf62 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human C16orf62 protein. Validated for ICC/IF applications. Antigen affinity purified and supplied as unconjugated liquid form. Ideal for research on endosomal retrieval and recycling mechanisms.
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Applications
Tested Application and Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human C16orf62. Recombinant protein control fragment (Product #RP-106474) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663843 |
Product Specific Information
Immunogen sequence:
FDFLLTFKQIH GDTVQNQLVV QGVELPSYLP LYPPAMDWIF QCISYHAPEA LLTEMMERCK KLGNNALLLN SVMSAFRAEF IATRSMDFIG M
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 95%
Target Information
Acts as a component of the retriever complex, a heterotrimeric complex related to the retromer cargo-selective complex (CSC). It is essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079).
The retriever complex recruitment to endosomal membranes involves CCC and WASH complexes (PubMed:28892079).
In endosomes, it drives retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, maintaining homeostasis of cell surface proteins involved in migration, adhesion, nutrient supply, and signaling.
Also involved in copper-dependent ATP7A trafficking between the trans-Golgi network and peripheral vesicles, functioning with CCC and WASH complexes on early endosomes.
Not required for CCC complex stability (PubMed:25355947). [UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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