Thermo Fisher Scientific C16orf62 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human C16orf62. Recombinant protein control fragment (Product #RP-106474). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C16orf62,uniProtId:Q7Z3J2-1,ncbiNodeId:9606,antigenRange:359-450,antigenLength:963,antigenImageFileName:PA5-65802_C16orf62_Q7Z3J2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65802_C16orf62_Q7Z3J2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663843

Product Specific Information

Immunogen sequence: FDFLLTFKQIH GDTVQNQLVV QGVELPSYLP LYPPAMDWIF QCISYHAPEA LLTEMMERCK KLGNNALLLN SVMSAFRAEF IATRSMDFIG M

Highest antigen sequence identity to the following orthologs - mouse 93%, rat 95%.

Target Information

Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.