Thermo Fisher Scientific FRS3 Polyclonal Antibody
FRS3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5101324
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FRS3 (Accession O43559), corresponding to amino acid residues E199–A249. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850761 |
Product Specific Information
This antibody detects endogenous levels of total SNT2.
Target Information
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein containing one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and links c-Fgr and NGF receptors to downstream signaling pathways. By interfering with phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. It likely interacts with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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