Thermo Fisher Scientific IL17RA Polyclonal Antibody
IL17RA 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot, IHC, ICC/IF에 사용 가능하며, 고순도 Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific IL17RA Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL17RA (Accession Q96F46), corresponding to amino acid residues F146–C196 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850763 |
Product Specific Information
Antibody detects endogenous levels of total IL17RA.
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It induces maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. The IL-17A/IL-17RA interaction plays a pathogenic role in inflammatory and autoimmune diseases such as rheumatoid arthritis.
Defects in IL-17RA cause familial candidiasis type 5 (CANDF5), a rare disorder characterized by altered immune responses and impaired clearance of fungal infections.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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