Thermo Fisher Scientific Protein APC Monoclonal Antibody (ALi 12-28)
인간 APC 단백질을 인식하는 Mouse monoclonal antibody (Clone ALi 12-28). IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. 단백질 A로 정제된 액상 형태이며, 1.0 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ALi 12-28 |
| Immunogen | Amino acids 1–433 N-terminal fragment of human APC (Adenomutons Polyposis Coli gene Chr 5q) fused to maltose binding protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_568441 |
Product Specific Information
This antibody does not cross-react with mouse.
Target Information
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is involved in processes such as cell migration, adhesion, transcriptional activation, and apoptosis.
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that often progresses to malignancy.
Disease-associated mutations are typically clustered in a region called the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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