Thermo Fisher Scientific CD23 Monoclonal Antibody (1B12)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: -
• Publications: View 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:40
• Publications: View 1 publication

Product Specifications

Product Specific Information

MA5-14054 targets CD23 in IHC (P) applications and shows reactivity with human samples.
The immunogen used is the recombinant external domain of the CD23 protein.

Target Information

CD23 is a 45 kDa glycoprotein expressed on a subset of freshly isolated peripheral blood and tonsil B cells, and strongly expressed on EBV-transformed B lymphoblasts. It is identical to the low-affinity IgE receptor found on B cells.
CD23 expression has been observed in neoplastic cells from B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lymphoma cases. Functionally, CD23 is involved in B cell growth, differentiation, and IgE production.
A soluble form of CD23 acts as a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.