Thermo Fisher Scientific Synuclein alpha/beta Recombinant Rabbit Monoclonal Antibody (ARC1181)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1181

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human alpha + beta Synuclein (P37840) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Synuclein alpha/beta,uniProtId:P37840-1,ncbiNodeId:9606,antigenRange:1-100,antigenLength:140,antigenImageFileName:MA5-35604_Synuclein_alphabeta_P37840-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35604_Synuclein_alphabeta_P37840-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:Synuclein alpha/beta,uniProtId:Q16143-1,ncbiNodeId:9606,antigenRange:1-100,antigenLength:134,antigenImageFileName:MA5-35604_Synuclein_alphabeta_Q16143-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35604_Synuclein_alphabeta_Q16143-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.35 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849504

Product Specific Information

Immunogen sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL

Target Information

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimers (AD), Parkinsons PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.