Thermo Fisher Scientific IPO5 Monoclonal Antibody (N9C1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-10 µg/mL

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N9C1

Immunogen

Proximal sequence element (PSE1) of the human U1 small nuclear RNA extracted from human placenta. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IPO5,uniProtId:O00410-1,ncbiNodeId:9606,antigenRange:1-1097,antigenLength:1097,antigenImageFileName:MA1-10886_IPO5_O00410-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10886_IPO5_O00410-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1086949

Product Specific Information

MA1-10886 detects PSE1/Ku Protein from human samples.

MA1-10886 has been successfully used in Western blot applications.

The MA1-10886 immunogen is Proximal Sequence Element (PSE1) of the human U1 small nuclear RNA extracted from human placenta.

Target Information

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.