Thermo Fisher Scientific GTF2B Monoclonal Antibody (IIB8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-10884 detects Transcription Factor IIB from human and mouse samples.
This antibody has been successfully used in ELISA, Western blot, and immunoprecipitation applications.
The immunogen used is recombinant human transcription factor IIB (TFIIB).

Target Information

Ubiquitin is a 76-amino-acid, highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome.
The ubiquitination process regulates the concentration of key cellular proteins by controlling their lifespans.
Polyubiquitination involves serial steps: activation of ubiquitin via ATP-dependent formation of a thioester bond with E1 enzyme, transfer to E2 conjugating enzyme, and covalent linkage to target proteins directly or via E3 ligase.
Deubiquitination enzymes can reverse this marking.
Ubiquitin tagging is involved in numerous cellular processes including cell cycle, growth, differentiation, apoptosis, signal transduction, DNA repair, transcription regulation, transport, stress response, immune response, and nervous system function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.