Thermo Fisher Scientific JIP3 Polyclonal Antibody
JIP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 147 kDa 단백질 검출에 유용.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 615–664 of human JIP-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553495 |
Product Specific Information
This antibody detects endogenous JIP3 protein at a molecular weight of 147 kDa.
Purity is >95% by SDS-PAGE.
Target Information
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family.
JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to UV light and phosphorylates c-Jun at amino-terminal serine sites (Ser63 and Ser73), leading to transcriptional activation.
JIP-1 (JNK interacting protein-1) acts as a cytoplasmic inhibitor of JNK, retaining JNK in the cytoplasm and inhibiting JNK-regulated gene expression.
Multiple splice variants of JIP proteins—including JIP-1b, JIP-1c (islet-brain 1 or IB-1), JIP-2a, JIP-2b, and JIP-3—have been identified in brain tissue.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-36369_JIP3_Q9UPT6-1_Rabbit.svg, PA5-36369_JIP3_Q9UPT6-1_Rabbit_PDP.jpeg)
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