Thermo Fisher Scientific NFATC2IP Polyclonal Antibody, MaxPab
NFATC2IP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS(pH 7.4) 용액 형태로 제공되며 방부제는 포함되지 않습니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | NFATC2IP (AAH21551.1, 1–138 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSEPLQSVVD HMATHLGVSP SRILLLFGET ELSPTATPRT LKLGVADIID CVVLTSSPEA TETSQQLQLR VQGKEKHQTL EVSLSRDSPL KTLMSHYEEA MGLSGRKLSF FFDGTKLSGR ELPADLGMES GDLIEVWG
Target Information
In T-helper 2 (Th2) cells, NFATC2IP regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5, and IL13, but not IL2. It recruits PRMT1 to the IL4 promoter, enhancing histone H4 Arg-3 methylation and facilitating subsequent histone acetylation at the IL4 locus, promoting robust cytokine expression. It also down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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