Thermo Fisher Scientific AIFM2 Monoclonal Antibody (2C6)
Thermo Fisher Scientific의 AIFM2 Monoclonal Antibody (2C6)은 인간 AIFM2 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot 및 ELISA에 적합하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C6 |
| Immunogen | AIFM2 (AAH06121, 1–339 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGSQVSVESG ALHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV AALRASVETG FAKKTFISYS VTFKDNFRQG LVVGIDLKNQ MVLLQGGEAL PFSHLILATG STGPFPGKFN EVSSQQAAIQ AYEDMVRQVQ RSRFIVVVGG GSAGVEMAAE IKTEYPEKEV TLIHSQVALA DKELLPSVRQ EVKEILLRKG VQLLLSERVS NLEELPLNEY REYIKVQTDK GTEVATNLVI LCTGIKINSS AYRKAFESRL ASSGALRVNE HLQVEGHSNV YAIGDCADVR TPKMAYLAGL HANIAVANIV NSVKQRPLQA YKPGALTFLL SMGRNDGVG
Target Information
The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses.
PRG3 (p53-responsive gene 3) is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells.
PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF.
Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis.
The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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