Thermo Fisher Scientific Phospho-JAK2 (Tyr1007, Tyr1008) Polyclonal Antibody
JAK2 단백질의 Tyr1007/1008 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 26 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Hamster, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from a region of mouse JAK2 containing tyrosines 1007 and 1008 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533649 |
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is known to be mutated in polycythemia vera. It contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to regulate transcription of interferon-stimulated and other genes. JAK2 is essential for IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Mutations in JAK2 are associated with disorders such as Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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