Thermo Fisher Scientific ADORA1 Recombinant Rabbit Monoclonal Antibody (ARC1987)
ADORA1 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Affinity chromatography 정제, 안정적 PBS/glycerol buffer 포뮬레이션. 연구용으로만 사용.
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Thermo Fisher Scientific ADORA1 Recombinant Rabbit Monoclonal Antibody (ARC1987)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1987 |
| Immunogen | Synthetic peptide within amino acids 100–200 of human ADORA1 (P30542) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898058 |
Product Specific Information
- Positive Samples: Raji, SH-SY5Y, Mouse liver, Mouse testis
- Immunogen sequence:
AIAVDRYLRV KIPLRYKMVV TPRRAAVAIA GCWILSFVVG LTPMFGWNNL SAVERAWAAN GSMGEPVIKC EFEKVISMEY MVYFNFFVWV LPPLLLMVLI Y
Target Information
Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical, and pharmacological analyses of AR genes and proteins have identified four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates various physiological processes including cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.
The A1AR subtype activates Gi and Go proteins, leading to inhibition of adenylyl cyclase and stimulation of phospholipase C, mobilizing intracellular calcium stores. A1AR also activates potassium channels, significantly impacting cardiovascular function. It is highly expressed in brain regions such as the cerebellum, hippocampus, thalamus, and cortex, modulating neurotransmitter release. In white adipocytes, A1AR inhibits lipolysis and promotes glucose uptake. Expression is also observed in kidney and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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