Thermo Fisher Scientific CD2 Polyclonal Antibody
CD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인체 반응성이 있으며 IHC(P) 등 다양한 연구용 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되어 안정성이 높고, PBS 버퍼에 보존되어 장기 보관이 가능합니다.
- 카탈로그번호
- 500-3044
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of CD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human tonsil tissue
- Cellular location: Membrane
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, present on more than 95% of thymocytes, and also found on some natural killer cells but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2 is the erythrocyte receptor or closely associated with it.
CD2 interacts with CD58 to stabilize adhesion between T cells and antigen-presenting cells. Although their affinity is relatively low in solution, it is compensated at the cell-cell interface to ensure strong adhesion.
T cell activation increases CD2 expression and lateral mobility, facilitating CD2–CD58 interaction and strengthening intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and helps control infection. Diseases associated with CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymus absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 500-3044_CD2_P06729-1_Rabbit.svg, 500-3044_CD2_P06729-1_Rabbit_PDP.jpeg)
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