Thermo Fisher Scientific H5N1 VN04-16 Monoclonal Antibody (18E1)

Applications

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This monoclonal antibody was clarified from mouse ascitic fluid and is specific for H5 hemagglutinin (HA) protein of influenza A virus [strain A/Vietnam/1203/04 (H5N1)].
VN04-16 monoclonal antibody did not cross-react with influenza viruses of other HA subtypes.
It reacted with H5N1 influenza virus representatives of different clades and subclades of the H5 HA subtype.

Target Information

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic.

Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins elicit immune responses that prevent infection or reduce viral replication.

The genetic make-up of the swine flu virus is unique: it is an H1N1 strain combining human, swine, and avian influenza genes with new pig H3N2 genes from Eurasia. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest limited human immunity, although older age groups may have partial protection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.