Thermo Fisher Scientific Zap-70 Monoclonal Antibody (ZAP-03)
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 재고 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
MA119443 | - | Thermo Fisher Scientific MA119443 Zap-70 Monoclonal Antibody (ZAP-03) 100 ug pk | 재고문의 | pk | 478,000원 | - | 525,800원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
0.5-2 µg/mL
Immunocytochemistry (ICC/IF)
Assay-dependent
Flow Cytometry (Flow)
2-5 µg/mL
Product Specifications
Species Reactivity
Human, Mouse
Host/Isotype
Mouse / IgG1
Class
Monoclonal
Type
Antibody
Clone
ZAP-03
Immunogen
Bacterially expressed fusion protein representing C-terminal part (160 amino acids) of human ZAP-70 with histidine tag if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
Zap-70,
uniProtId:
P43403-1,
ncbiNodeId:
9606,
antigenRange:
619,
antigenLength:
619,
antigenImageFileName:
MA1-19443_Zap-70_P43403-1_House_mouse.svg,
antigenImageFileNamePDP:
MA1-19443_Zap-70_P43403-1_House_mouse_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1088337
Product Specific Information
This antibody reacts with ZAP70, a 70 kDa protein tyrosine kinase expressed in T and NK cells (intracellular antigen). ZAP70 is a molecule susceptible to degradation. It is recommended to use freshly prepared cell lysates (protease inhibitors are essential) to avoid non-specific staining of degradation products.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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