Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4028)
Effector T 세포 마커 TIM3/HAVCR2/CD366를 인식하는 Mouse Monoclonal Antibody. Western blot, IHC 등 다양한 응용 가능. Human 반응성, Protein A/G 정제, 액상 형태로 제공. 면역조절 및 자가면역 연구에 적합.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4028)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/4028 |
| Immunogen | Recombinant fragment of human TIM3 protein (around aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 plays roles in macrophage activation and autoimmune disease induction. It down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance development.
Pathologically, TIM3 is associated with Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and enhances its severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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