Thermo Fisher Scientific TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4027)
Effector T 세포 마커인 TIM3/HAVCR2/CD366를 인식하는 Mouse Monoclonal Antibody. Western Blot 및 Immunohistochemistry에 사용 가능. Human 시료 반응. Protein A/G 정제, PBS 용액 형태, 보존제 없음. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/4027 |
| Immunogen | Recombinant fragment of human TIM3 protein (aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and autoimmune disease induction, and it down-regulates Th1-mediated immune responses, promoting immune tolerance.
Pathological relevance includes experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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