Thermo Fisher Scientific Mouse ICAD Synthetic Peptide
마우스 ICAD 단백질의 카르복시 말단 20개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-19890의 블로킹 펩타이드로 사용 가능. 액상 형태, PBS 버퍼(0.1% BSA 포함) 내 200 µg/mL 농도. -20°C에서 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the carboxy terminus of mouse ICAD.
PEP-0018 can be used as a blocking peptide with polyclonal antibody PA5-19890.
Target Information
ICAD (Inhibitor of Caspase-3-Activated DNase) acts as a substrate controlling nuclear apoptosis. It has two isoforms:
- ICAD-L/DFF45 (45 kDa): Functional isoform
- ICAD-S/DFF35 (35 kDa): Non-functional isoform
ICAD binds and inhibits CAD (Caspase-Activated DNase). During apoptosis, caspase-3 cleaves ICAD at residues 117 and 224, releasing CAD to execute DNA fragmentation.
ICAD also functions as a CAD-specific folding chaperone and has been identified as a potential target for restoring apoptotic signaling in colon and brain cancer cells.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified for the ICAD gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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