Thermo Fisher Scientific LPIN3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–3 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

Human lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin.
Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes, indicating that lipin is required for normal adipose tissue development and providing a candidate gene for human lipodystrophy.

Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs.

• Human LPIN1: mapped to 2p25 (linked to fat mass and serum leptin levels)
• Human LPIN2: mapped to 18p11
• Human LPIN3: mapped to 20q11–q12
• Mouse Lpin1, Lpin2, Lpin3: mapped to chromosomes 12, 17, and 2, respectively.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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