Thermo Fisher Scientific Cul4B Polyclonal Antibody
Rabbit polyclonal antibody targeting human Cullin 4B (residues 863–913). Suitable for WB, IHC, IHC-P, and IP applications. Unconjugated, liquid form, 1 mg/mL concentration. Supports studies on ubiquitination and DNA repair mechanisms. For research use ...
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Thermo Fisher Scientific Cul4B Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 863 and 913 of human Cullin 4B (UniProt ID: Q13620-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
CUL4B is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes, mediating ubiquitination and proteasomal degradation of target proteins. It acts as a scaffold protein, positioning substrates and ubiquitin-conjugating enzymes for catalysis.
CUL4B participates in polyubiquitination of CDT1, histones H2A, H3, and H4 in response to DNA damage, and is targeted to UV-damaged chromatin by DDB2, playing a role in DNA repair and replication. It is required for cyclin E ubiquitination and normal G1 cell cycle progression, and regulates the mTOR pathway controlling cell growth and metabolism. Specific regulation of the mTORC1 pathway by CUL4B depends on 26S proteasome function and interaction with MLST8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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