Thermo Fisher Scientific TNFAIP8 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, HeLa
• Predicted reactivity: Mouse (94%), Rat (93%), Xenopus laevis (84%), Pig (95%), Chicken (89%), Rhesus Monkey (98%), Bovine (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2, or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF.
The induction of TNFalpha-IP 8 by TNF is dependent on NFkappa B activation.
It negatively mediates apoptosis and may play a role in tumor progression. TNFalpha-IP 8 inhibits caspase-8 activity, preventing BID cleavage and caspase-3 activation during TNF-mediated apoptosis.
It is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney.
TNFalpha-IP 8 exists as three isoforms produced by alternative splicing.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.