Thermo Fisher Scientific TRIB1 Polyclonal Antibody
TRIB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 IHC(파라핀)에서 검증됨. 다양한 종에서 예측 반응성을 보이며, 연구용 단백질 발현 및 신호전달 연구에 적합. 4°C 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 104–372 of Human TRIB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546883 |
Product Specific Information
- Recommended positive controls: A431, HeLa
- Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (81%), Dog (97%), Rhesus Monkey (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRIB1 (also known as gprotein coupled receptor induced, skip1, gig2, c8fwATP) functions in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells represses IL8 promoter activity by inhibiting AP1. It also inhibits oncogenic Ras-driven and MEKK1-mediated AP1 activation, while enhancing ERK activation. MEK1 interacts with both TRIB1 and TRIB3, and MKK4 interacts specifically with TRIB1, stabilizing TRIB1 through TRIB-MAPKK interaction.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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