Thermo Fisher Scientific CD16 Monoclonal Antibody (3G8), Alexa Fluor 700

Applications

• Flow Cytometry (Flow): Assay-dependent
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Product Specifications

Additional Formats

• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 700
• PE-Texas Red
• PerCP
• Request custom conjugation available

Product Specific Information

The Alexa Fluor™ 700 dye conjugate provides an excellent spectral match to common long-wavelength excitation sources, with a high extinction coefficient.

Target Information

CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in immune complex clearance and cellular-mediated cytotoxicity.
This gene (FCGR3A) shares high similarity with FCGR3B on chromosome 1.

• Expression: FCGR3A is expressed on NK cells as an integral membrane glycoprotein; FCGR3B is expressed on polymorphonuclear neutrophils (PMN).
• Anchoring: FCGR3A uses a transmembrane peptide; FCGR3B uses a phosphatidylinositol (PI) linkage.
• Clinical relevance: Mutations are associated with Immunodeficiency 20, recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
• Variants: Alternatively spliced transcript variants encoding different isoforms have been identified.

Classification

Analyte Specific Reagent

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