Thermo Fisher Scientific CD71/Transferrin Receptor (TFRC) Monoclonal Antibody (TFRC/1396)
CD71/Transferrin Receptor 단일클론 항체로 인간 TFRC 단백질을 표적으로 함. IHC, ICC/IF, Flow Cytometry에 적용 가능. 고순도 Protein A/G 정제, 보존제 무첨가 PBS 용액 형태. 세포 내 철 흡수 연구 및 빈혈 관련 진단 연구용에 적합.
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- 7037-MSM6-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TFRC/1396 |
| Immunogen | Recombinant human TFRC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome, and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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