Thermo Fisher Scientific CD71/Transferrin Receptor (TFRC) (Extracellular Domain) Monoclonal Antibody (TFRC/1817)
인간 TFRC(CD71) 단백질의 세포외 도메인을 인식하는 마우스 단클론 항체. Western blot, IHC, ELISA 등 다양한 면역실험에 사용 가능. Protein A/G 정제, 1 mg/mL 농도, PBS(pH 7.4) 용액 형태로 제공. 연구용으로만 사용.
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- 7037-MSM7-P1ABX
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TFRC/1817 |
| Immunogen | Recombinant extracellular fragment (around aa 94–212) of human TFRC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release, and the apotransferrin-receptor complex is recycled to the cell surface. Transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) is used to detect erythropoietin (EPO) misuse and diagnose various anemias related to conditions such as rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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