Thermo Fisher Scientific Human DIS3 Synthetic Peptide
인간 DIS3 단백질의 N-말단 서열에 해당하는 합성 펩타이드로, PA5-34549 항체의 블로킹 펩타이드로 사용 가능. 액상 형태, 200 µg/mL 농도, PBS(pH 7.2) + 0.1% BSA + 0.02% sodium azide 저장. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to the amino terminus of human DIS3.
PEP-1592 can be used as a blocking peptide with polyclonal antibody PA5-34549.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
The exosome is involved in a multitude of cellular RNA processing and degradation events.
DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species.
DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain.
It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression.
Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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