Thermo Fisher Scientific TRPV6 Polyclonal Antibody
Zebrafish TRPV6 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC에 사용 가능. 내부 영역 합성 펩타이드로부터 제작. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용 전용 제품.
- 카탈로그번호
- OST00377W-100UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of zebrafish TRPV6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPV6.
Target Information
Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal calcium reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs via rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties, and TRPV5–TRPV6 heteromultimers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin. Interaction with S100A10 is required for trafficking to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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