Thermo Fisher Scientific TRPV1 Polyclonal Antibody
TRPV1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC에 적합합니다. Chicken TRPV1 펩타이드를 면역원으로 제작되었으며, 비결합(Unconjugated) 형태의 동결건조 제품입니다. 연구용으로만 사용 가능하며, 감각신경 관련 연구에 유용합니다.
- 카탈로그번호
- OST00382W-100UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous (PubMed) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 600–660 of chicken TRPV1 (Vanilloid receptor-like protein, VR1, capsaicin receptor) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TRPV1.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
It is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6, permeable to calcium, magnesium, sodium, and potassium ions.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. It is activated by noxious heat and functions as a transducer of painful thermal stimuli.
TRPV1 mediates proton influx and may be involved in intracellular acidosis in nociceptive neurons. Expression is mainly limited to neurons within sensory ganglia.
Four transcript variants encoding TRPV1 with variations in the 5’ UTR sequence have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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