Thermo Fisher Scientific JMJD1A Polyclonal Antibody
JMJD1A 단백질을 표적하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Human 및 Rat 반응성. Antigen affinity chromatography로 정제된 액상 시약. 2–8°C 보관, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the amino terminus of human JMJD1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152901 |
Product Specific Information
- Suggested positive control: mouse liver tissue lysate
- PA5-20802 can be used with blocking peptide PEP-0916
Target Information
JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, playing a central role in the histone code. It preferentially demethylates mono- and dimethylated H3 Lys-9 residues (especially dimethylated), with weak or no activity on trimethylated H3 Lys-9. Demethylation of Lys residues generates formaldehyde and succinate.
JMJD1A is involved in hormone-dependent transcriptional activation by recruiting androgen-receptor target genes, resulting in H3 Lys-9 demethylation and transcriptional activation. It is also involved in spermatogenesis by regulating expression of genes such as PRM1 and TMP1, required for sperm chromatin packaging and condensation. Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항원 이미지: PA5-20802_JMJD1A_Q9Y4C1-1_Rabbit_PDP.jpeg)
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