Thermo Fisher Scientific JMJD1C Polyclonal Antibody
JMJD1C 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ChIP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. 인간, 마우스, 랫트 반응성. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide from near the amino terminus of human JMJD1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153212 |
Product Specific Information
- A suggested positive control is human liver tissue lysate.
- PA5-20804 can be used with blocking peptide PEP-0918.
Target Information
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in nuclear hormone receptor-based transcriptional regulation.
JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells, pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contains bHLH-, AP-1-, and POU5F1-binding sites. POU5F1-mediated expression of JMJD1C is suggested to reactivate previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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