Thermo Fisher Scientific SOCS7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SOCS7. Recombinant protein control fragment (Product #RP-102085). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SOCS7,uniProtId:O14512-1,ncbiNodeId:9606,antigenRange:127-269,antigenLength:581,antigenImageFileName:PA5-52079_SOCS7_O14512-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52079_SOCS7_O14512-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647738

Product Specific Information

Immunogen sequence: LETNSCSEEE LSSPGRGGGG GGRLLLQPPG PELPPVPFPL QDLVPLGRLS RGEQQQQQQQ QPPPPPPPPG PLRPLAGPSR KGSFKIRLSR LFRTKSCNGG SGGGDGTGKR PSGELAASAA SLTDMGGSAG RELDAGRKPK LTR

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Target Information

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.