Thermo Fisher Scientific GSTA3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
GKLRNDGSLM FQQVPMVEID GMKLVQTRAI LNYIASKYNL YGKDIKERAL IDMYTEGMAD LNEMILLLPL CRPEEKDAKI ALIKEKTKSR YFPAFEKVLQ SHGQDY

Highest antigen sequence identity to the following orthologs:

• Mouse: 79%
• Rat: 77%

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the alpha class genes located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged, accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity.
The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full-length sequence has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.