Thermo Fisher Scientific Phospho-PERK (Thr982) Polyclonal Antibody
PERK 단백질의 Thr982 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능합니다. 고순도 정제된 액상 형태로 제공되며, 인산화 PERK 검출 연구에 적합합니다.
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Thermo Fisher Scientific Phospho-PERK (Thr982) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EIF2AK3 (Accession Q9NZJ5), corresponding to amino acid residues around phosphorylated Thr982. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815938 |
Product Specific Information
Antibody detects endogenous levels of PERK only when phosphorylated at Thr982.
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis.
In the case of EIF2AK3, signaling is initiated by misfolded proteins in the endoplasmic reticulum (ER).
Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), a rare autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation, and multisystem manifestations including hepatic and renal dysfunctions, mental retardation, and cardiovascular abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-102853_PERK_Q9NZJ5-1_Rabbit.svg, PA5-102853_PERK_Q9NZJ5-1_Rabbit_PDP.jpeg)
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