Thermo Fisher Scientific CRMP1 Polyclonal Antibody
CRMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 IHC에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.02% sodium azide가 포함되어 있으며, 냉장(2–8°C) 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human CRMP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155622 |
Product Specific Information
- Suggested positive control: rat brain tissue lysate
- PA5-20677 can be used with blocking peptide PEP-0795.
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and olfactory system suggests involvement in adult brain plasticity.
CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in the brain. Later studies indicate its role in neurotrophin (NT)-3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting involvement in early neuronal differentiation and later processes related to neuronal survival or death.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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