Thermo Fisher Scientific FLT4 Monoclonal Antibody (OTI8C2), TrueMAB
인간 FLT4 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. VEGFR-3 연구 및 혈관 발달 관련 연구에 유용합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1063–1363 of human FLT4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues.
Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3.
In 1998, Dumont demonstrated that targeted inactivation of the VEGFR-3 gene in mice caused defective blood vessel development in early embryos, leading to cardiovascular failure at embryonic day 9.5.
Thus, VEGFR-3 plays an essential role in embryonic cardiovascular system development prior to lymphatic vessel formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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