Thermo Fisher Scientific Girdin Polyclonal Antibody
Girdin 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 Immunohistochemistry에 사용 가능하며, 액상 형태로 1 mg/mL 농도입니다. 세포 이동 및 암 전이 연구에 유용한 연구용 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the carboxy terminus of human Girdin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151921 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20869 can be used with blocking peptide PEP-0983.
Target Information
Girdin is a Galpha-interacting protein that enhances activation of the protein kinase Akt, remodels the actin cytoskeleton, and is involved in cell migration and cancer metastasis.
It interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is involved in migration, positioning, and differentiation of dentate granule cells (DGCs) during development.
Depletion of Girdin or blocking the Girdin–DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and abnormal migration of DGCs, suggesting Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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