Thermo Fisher Scientific CALM Polyclonal Antibody
CALM(PICALM) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot과 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS에 0.02% sodium azide가 포함된 액상 형태입니다. 냉장 보관(2–8°C) 가능하며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA520871
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human PICALM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155022 |
Product Specific Information
- A suggested positive control is EL4 cell lysate.
- PA5-20871 can be used with blocking peptide PEP-0985.
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area. It is an important component of the coated pit internalization machinery.
Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is expressed in neurons and facilitates the endocytosis of the synaptic vesicle protein VAMP2.
Recent studies have identified variants of PICALM associated with Alzheimer’s disease, suggesting its role in endocytosis and recycling of the amyloid protein precursor (APP).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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