Thermo Fisher Scientific DACT1 Monoclonal Antibody (OTI13H4), TrueMAB
Human DACT1 단백질을 인식하는 Mouse Monoclonal Antibody로, Western Blot에 최적화되어 있습니다. Lyophilized 형태이며, PBS buffer와 trehalose를 포함합니다. 연구용으로만 사용되며, Wnt 신호전달 관련 연구에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 289–555 of human DACT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Dapper homolog 1 (DACT1), an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism.
It interacts with Dvl through the DEP domain and the central/C-terminal regions of DACT1.
The human DACT1 gene is located on chromosome 14q23.1 and regulates CTNNB1/beta-catenin degradation, enhancing Wnt pathway transcriptional activation.
DACT1 is essential for normal notochord formation and is downregulated in hepatocellular carcinoma (HCC). It is expressed in human liver and various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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