Thermo Fisher Scientific SLUG Monoclonal Antibody (4B6D5)
SLUG 단백질을 인식하는 Mouse monoclonal antibody(클론 4B6D5)로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B6D5 |
| Immunogen | Purified recombinant fragment of human SNAI2 (aa 100–200) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898546 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Slug transcription can be induced by FGF, BMP, and TGF-beta, and it represses genes such as E-cadherin and Claudin-1. Its expression in breast, esophageal, and colorectal carcinomas correlates with poor prognosis. Slug also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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