Thermo Fisher Scientific SMAD1 Monoclonal Antibody (4E12H10)
SMAD1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 4E12H10). Western blot 및 ELISA에 적합하며, 인간, 마우스, 비인간 영장류 시료에 반응. Protein G 정제, 1 mg/mL 농도, PBS에 0.05% sodium azide 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E12H10 |
| Immunogen | Purified recombinant fragment of human SMAD1 (aa 1–110) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898545 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila mothers against decapentaplegic (Mad) and the C. elegans Sma gene products.
SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates signals of bone morphogenetic proteins (BMPs), which regulate cell growth, apoptosis, morphogenesis, development, and immune responses.
Upon BMP ligand binding, this protein is phosphorylated and activated by BMP receptor kinase, forming a complex with SMAD4 for transcriptional regulation.
It is also targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) for ubiquitination and proteasomal degradation.
Alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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