Thermo Fisher Scientific STAT1 Polyclonal Antibody
STAT1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC 등 다양한 응용에 적합. Rabbit/IgG 호스트 기반으로 고순도 Protein G 정제. Human, Mouse 등 여러 종에 반응하며, 세포 신호전달 및 유전자 발현 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Pig |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 700–750 of human STAT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2198291 |
Product Specific Information
- Predicted to react with chicken and rat samples based on sequence homology.
- Sequence is 100% conserved between Stat1 alpha and Stat1 beta.
- Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
STAT1 (Signal Transducers and Activators of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism.
STAT1 plays a critical role in mediating cell viability in response to various stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2 and is activated by extracellular signaling molecules such as cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 translocates to the nucleus to regulate transcription of multiple genes.
Among the seven STAT types (STAT1, STAT3, STAT5a, STAT5b, etc.), STAT1 has a broad activation profile and responds to ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-Gamma, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct STAT1 isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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