Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody, MaxPab

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein Sequence:

MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA EALLQSMGLT PESPIVPPPM SPSSKSVSTP SEAGSQDSGD GAVGSRRGPI KLGMAKITQV DFPPREIVTY TKETQTPVMA QPKEDEEEDD DVVAPKPPIE PEEEKTLKKD EENDSKAPPH ELTEEEKQQI LHSEEFLSFF DHSTRIVERA LSEQINIFFD YSGRDLEDKE GEIQAGAKLS LNRQFFDERW SKHRVVSCLD WSSQYPELLV ASYNNNEDAP HEPDGVALVW NMKYKKTTPE YVFHCQSAVM SATFAKFHPN LVVGGTYSGQ IVLWDNRSNK RTPVQRTPLS AAAHTHPVYC VNVVGTQNAH NLISISTDGK ICSWSLDMLS HPQDSMELVH KQSKAVAVTS MSFPVGDVNN FVVGSEEGSV YTACRHGSKA GISEMFEGHQ GPITGIHCHA AVGAVDFSHL FVTSSFDWTV KLWTTKNNKP LYSFEDNADY VYDVMWSPTH PALFACVDGM GRLDLWNLNN DTEVPTASIS VEGNPALNRV RWTHSGREIA VGDSEGQIVI YDVGEQIAVP RNDEWARFGR TLAEINANRA DAEEEAATRI PA

Target Information

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light, and light-intermediate chains are all components of minus end-directed motors, responsible for transporting cellular cargos toward the cell center. Axonemal Dynein motors, containing one to three non-identical heavy chains, facilitate microtubule sliding in cilia and flagella, enabling motility. Cytoplasmic Dynein is a complex of approximately 12 subunits, including two heavy chains, two intermediate chains for cargo anchoring, four smaller intermediate chains, and several light chains. It plays essential roles in organelle transport and centrosome assembly. The carboxy-terminus of Dynein is critical for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Dynein activity is regulated by proteins such as Dynactin, LIS1, and Nudel (NudE-like).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.