Thermo Fisher Scientific Phospho-TGFBR2 (Tyr284) Polyclonal Antibody
TGFBR2 Tyr284 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot 및 IHC(Paraffin)에서 사용 가능. 고순도 액상형으로 PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-TGFBR2 (Tyr284) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TGFBR2 (Accession P37173), corresponding to amino acid residues around phosphorylated Tyr284 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817319 |
Product Specific Information
Antibody detects endogenous levels of TGFBR2 only when phosphorylated at Tyr284.
Target Information
Transforming Growth Factor, beta receptor 2 (TGFBR2; also known as AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases involved in the regulation of cell proliferation.
TGFBR2 encodes the gamma subunit of the catalytic core of mitochondrial ATP synthase, which catalyzes ATP synthesis utilizing an electrochemical proton gradient across the inner membrane during oxidative phosphorylation.
ATP synthase consists of two linked multi-subunit complexes: the soluble catalytic core (F1) and the membrane-spanning proton channel component (Fo). The F1 portion comprises five subunits (α, β, γ, δ, ε) with a stoichiometry of 3α, 3β, and one each of γ, δ, ε. The Fo portion includes three main subunits (a, b, c).
Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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