Thermo Fisher Scientific Phospho-TBK1 (Ser172) Polyclonal Antibody
TBK1 단백질의 Ser172 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. 면역 및 염증 반응 연구에 적합.
- 카탈로그번호
- PA5105919
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TBK1 (Accession Q9UHD2), corresponding to amino acid residues around phosphorylated Ser172. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817318 |
Product Specific Information
This antibody detects endogenous levels of TBK1 only when phosphorylated at Ser172.
Target Information
TBK1 (TANK-binding kinase 1) is a serine/threonine kinase belonging to the IKK family, involved in NF-kappa B activation and IRF3 signaling. It plays a key role in immune and inflammatory response regulation.
Phosphorylation of I-KB by the IKK complex leads to NF-kB activation. TBK1, also known as NAK (NF-kB-activating kinase) or T2K, activates IKK beta through direct phosphorylation and functions upstream of NIK and the IKK complex. TBK1 is also critical for protecting embryonic liver cells from apoptosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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