Thermo Scientific™

GeneBLAzer™ PTGDR-CRE-bla CHO-K1 Cells

GeneBLAzer™ PTGDR-CRE-bla CHO-K1 cells contain the human Prostanoid (PTGDR) Receptor stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™자세히 알아보기

GeneBLAzer™ PTGDR-CRE-bla CHO-K1 cells contain the human Prostanoid (PTGDR) Receptor stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer™ PTGDR-CRE-bla CHO-K1cells are functionally validated for Z` and EC50 concentrations of Prostaglandin D2. In addition, GeneBLAzer™ PTGDR-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The PTGDR receptor also known as DP, is a Gs-coupled receptor which activates adenylate cyclase. PTGDR receptors are located in vascular smooth muscle cells and blood platelets, and are also believed to be expressed in the brain, where they may be involved in the regulation of sleep. In addition, knockout studies in mice suggest that PTGDR may be involved in allergic and asthmatic responses. Potent agonists and antagonists for PTGDR have been identified.

사양

등록 번호NM_000953.2

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

검출 방법Fluorescence

용도(애플리케이션)FRET

유전자 기호PTGDR

개체군 상태Single Cell Clone Origin

제품라인GeneBLAzer™

수량2 x 106 Cells

리포터 유전자BLA (Beta-Lactamase)

타겟 입력PTGDR

세포주CHO-K1

System TypeGeneBLAzer™

Druggable TargetGPCR

Unit SizeEach