Thermo Fisher Scientific Mast Cell Chymase Monoclonal Antibody (CC1)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 3 publications 3 publications

Immunohistochemistry (IHC)

-

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Published species

Dog, Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CC1

Immunogen

Purified human skin chymase if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Mast Cell Chymase,uniProtId:P23946-1,ncbiNodeId:9606,antigenRange:1-247,antigenLength:247,antigenImageFileName:MA5-11717_Mast_Cell_Chymase_P23946-1_House_mouse.svg,antigenImageFileNamePDP:MA5-11717_Mast_Cell_Chymase_P23946-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984248

Product Specific Information

MA5-11717 targets Mast Cell Chymase in IHC (P) and WB applications and shows reactivity with Human samples.

The MA5-11717 immunogen is purified human skin chymase.

Target Information

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.