Thermo Fisher Scientific Phospho-MDMX (Ser367) Polyclonal Antibody
Phospho-MDMX (Ser367) 폴리클로날 항체로, 인산화된 MDMX 단백질의 Ser367 부위를 특이적으로 인식합니다. Western blot 및 Immunocytochemistry에 사용 가능하며, 사람, 생쥐, 랫드 반응성을 가집니다. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MDM4 (Accession O15151), corresponding to amino acid residues around phosphorylated Ser367 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816811 |
Product Specific Information
This antibody detects endogenous levels of MDM4 only when phosphorylated at Ser367.
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene encoding MDMX is often amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, leading to increased p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. MDMX also binds p73 and stabilizes its level, increasing its half-life by binding to MDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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